Hello Everyone,

I was wondering if anyone if anyone else has tried Colostrinin (Sold as Cognisure in the States). It is a recent nutractutical that is extracted from bovine Colostrum. It has helped me with memory improvement. A pharmaceutical version is being developed also.

Never heard of it but I do believe there is a cure for everything in nature. We just need to find it.

Hi RG welcome to the board! I haven't heard of it, but if the basis is bovine Colostrum I'm sure it has some level of benefit. The biggest contibution bovine Colostrum has is on immunity and inflammation, both big factors in AD development (so the scientific community believes). I would have to see the study to determine if this truly has an effect.

http://surfer.iitd.pan.wroc.pl/journals ... 47z608.pdf

http://www.ncbi.nlm.nih.gov/pubmed/?term=colostrinin

Hi Guys, thanks for he welecome and response. I agree that Colstrum is good, as I have used to to cure sore throats. This is what led me to try cognisure.

I understand that Colostrum itself does not help with AD, but an a element that has been extracted from it, ie: PRP which is known as colostrinin or cognisure.

A couple of links showing the research done may be of interest. A pharma version is being developed too, not just a nutraceutical.

all the very best, RG

Taken from another AD message board:




Alzheimer's Disease

"New understandings in the treatment of AD"

Due to the failure of drugs having any significant impact on the condition, research into the treatment for Alzheimer's has been redirected to discovering possible treatments using colostrum extracts. ReGen Therapeutics has played a major role in this development and now is in the position after many years of research to release a product onto the market place which has been trademarked under the name of Colostrinin™. It has been under development as a neutraceutical treatment for 'the prevention of cognitive decline' in both humans and animals. In particular, diseases such as such as Alzheimer's and possibly the treatment of Parkinson's Disease.

From a general terminology point of view, Colostrinin is a proline-rich polypeptide complex produced from colostrum (a mammal's first milk) and is being developed as a nutraceutical for use in humans and animals for the prevention of early stage cognitive decline and is in advanced development as a treatment for Alzheimer's disease. Current research has been promising with Colostrinin™ showing efficacy in a 106 patient, placebo controlled trial conducted in mild/moderate Alzheimer's sufferers over 30 weeks. Results announced in April 2005 indicate that peptides within Colostrinin may have potential as a therapy for Parkinson's disease as well.

Colostrinin™ is ReGen's lead compound, which as mentioned is a proline-rich polypeptide complex produced from colostrum (a mammals' first milk after birth). In in vitro studies Colostrinin™ has been shown to prevent the aggregation of beta-amyloid and reduce it’s toxicity to cells. Beta-amyloid is the toxic peptide that is the main constituent of the characteristic plaques’ that form in the brains of people with Alzheimer’s disease and cause loss of cognitive function. Colostrinin™ has also been shown to protect cells from oxidative stress another of the pathologies implicated in Alzheimer’s disease. In in vivo studies Colostrinin™ has been shown to improve memory performance of aged rats in the Morris water maze test. Colostrinin has shown efficacy in a 106 patient, placebo controlled trial conducted in mild/moderate Alzheimer's sufferers over 30 weeks. Furthermore, Colostrinin™ and a synthetic homologue of Colostrinin™-derived peptide show neuroprotection in a cell line model of Parkinson's disease. An in vitro study has shown that pre-treatment with Colostrinin™ and a synthetic version of a peptide shown to occur naturally in Colostrinin™ can protect cells of the kind that are depleted in Parkinson's disease from damage by a chemical known to be selectively toxic to them. The initial data from this study suggests that Colostrinin™ and peptides within it may protect dopaminergic neurones against degeneration.

An in vitro study has shown that Colostrinin™ can cause precursor nerve cells to differentiate and proliferate. These findings suggest that Colostrinin™ treatment may control the expression of genes that are involved in the development, maintenance, and regeneration of neurons in the central nervous system, and thus may also explain the improvements observed in Alzheimer's patients with mild-to-moderate dementia during treatment with Colostrinin™.

A further in vitro study has shown that Colostrinin™ increases the lifespan of cells isolated from inbred mice predisposed to premature ageing and therefore, death. This study shows the impact of Colostrinin™ on the mitochondria of cells isolated from strains of senescence-prone (SAMP1) and senescence-resistant (SAMR1) mice. The data show that cells from SAMP1 mice produce more ROS, exhibit severe mitochondrial dysfunction, and have a decreased lifespan compared to the cells from SAMR1 mice. Addition of Colostrinin™ to SAMP1 cells significantly decreased ROS levels, normalized mitochondrial function and increased the lifespan to levels similar to those in SAMR1 cells. This is an exciting finding that may go toward explaining the cognitive benefits of Colostrinin™ seen in clinical studies. In vivo experiments are now ongoing to test if these effects are evident when SAMP1 and SAMR1 mice are given Colostrinin™ over their lifetime.

Having now achieved the production of Colostrinin™ at industrial scale ReGen announces that it is starting formal safety studies with Colostrinin™. While there have been no safety concerns associated with the use of Colostrinin™ in previously conducted safety or clinical studies, this is a key milestone for ReGen as these earlier studies used Colostrinin™ made with a small-scale process and using ovine rather than bovine colostrum. In parallel with the safety program, work continues to complete the incorporation of Good Manufacturing Practise (GMP) into the production process.

Last September ReGen presented preliminary evidence of an anti-ageing effect from Colostrinin™ at the 21st International Conference of Alzheimers Disease International taking place in Istanbul. Researchers saw that the product increased the lifespan of cells isolated from mice predisposed to premature ageing and therefore, death, when they tested its impact on the mitochondria of cells isolated from strains of senescence-prone (SAMP1) and senescence-resistant (SAMR1) mice.

While cells from SAMP1 mice produce more reactive oxygen species (ROS), exhibit severe mitochondrial dysfunction, and have a decreased lifespan compared to the cells from SAMR1 mice, adding Colostrinin significantly decreased ROS levels, normalized mitochondrial function and increased the lifespan to levels similar to those in SAMR1 cells.

Continuous low levels of oxidative damage to cells, caused by ROS, play a key role in age-associated neurodegenerative diseases such as Alzheimer's, Parkinson's disease and other disorders of the central nervous system.

Conclusion:

Based on current research, Colostrinin has the potential as a treatment for Alzheimer’s disease, Parkinson's disease and other neurodegenerative disease conditions.